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In the event of an infection, antibiotics are routinely prescribed to alleviate the infection by killing the culprits responsible, specifically the bacteria. However, we now know that bacteria avoid being destroyed by blocking the antibiotic from entering the site of the infection; by altering the target site (the location of the infection) to the extent that the antibiotic is not effective; by generating mutations of themselves that then become resistant bacteria; or by exchanging molecules with non-resistant bacteria, making these non-resistant bacteria resistant to the antibiotic. Further, there are now strains of bacteria that are resistant to several antibiotic drugs; these multi-drug resistant bacteria, called super bugs, once associated with vulnerable populations such as patients in nursing homes, organ transplant patients, and patients with HIV, have made their way to the population at large.1
Bacterial resistance to antibiotic drugs is related to the number of times a particular antibiotic is used; and in some instances, the size of the dose. All of us can remember times that we made a physician appointment with a cough or cold or earache with one purpose in mind, to leave the office with a prescription for an antibiotic. Such expectations combined with the belief that an antibiotic is the sole solution for treating an infection are responsible for millions of prescriptions for antibiotics each year. These prescriptions may or may not be helpful and over time contribute to drug resistance.2 Conversely, antibiotic prescriptions are always issued with the caveat that the drug should be continued until the prescription is completed. In the usual instance, this means taking the antibiotic three-to-four times a day for a week to ten days; however when people start feeling better they may think that they can stop taking the antibiotic, saving it for another time when they may need to take it again. This is not wise and here is why. In the initial days of treatment, only the weakest of the bacteria are eliminated; thus when a person stops taking the medication earlier than prescribed, the net result is that strong, increasingly resistant bacteria survive.
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The single most important thing anyone can do to insure that they do not acquire and/or transmit infection caused by resistant bacteria is to wash their hands frequently. In addition, anyone coughing or sneezing should use the inside surface of the arm near the juncture of the elbow to block the transmission of droplets containing the bacteria.3 Its not that using your hand won’t stop the transmission of the bacteria through the air, but it is because your hand will harbor the bacteria that can later be transmitted through a handshake or by touching people or things people will use. This simple change combined with frequent hand washing can help insure that infected persons and those who have had contact with the bacteria do not transmit the bacteria to others.
In summary, everyone should realize that bacteria will find ways to survive and eventually will evolve to resist the drugs intended to cause their destruction. While it is not as yet possible to stop bacteria from becoming resistant, it is possible to slow the process of resistance. Everyone should understand that bacteria will continuously work toward their own survival by altering the environment in which they find themselves or by altering their own structures. Therefore, there is need for all to be aware that each instance of the use of a particular antibiotic contributes to bacterial resistant. Further, while there will always be need for continuous development of new antibiotics to combat resistant bacteria, antibiotics currently available should be used prudently to insure their effectiveness for a longer period of time.
1. Atlantis, A.J., Resistance to antibiotics: are we in the post-antibiotic era? Archives of Medical Research, 2005. 36(6): p. 697-705.
2. Huang, N., et al., A<>ntibiotic prescribing for children with nasopharyngitis, upper respiratory infections, and bronchitis who have health-professional parents. Pediatrics, 2005. 116(4): p. 826-832.
3. Deardorff, J., Fighting flu: the best defense is a good offense, in Chicago Tribune. October 25, 2005: Chicago Illinois. p. 1(13).
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